Os Prémios Screen Actors Guild para Melhor Actriz numa Série de Comédia são dados pelos Screen Actors Guild para honrar as melhores realizações de uma actriz no gênero comédia televisivo.

Vencedoras e nomeadas Anos 1990

1994: Helen Hunt, em Mad About You Ellen DeGeneres, em Ellen Candice Bergen, em Murphy Brown Roseanne Barr, em Roseanne Julia Louis-Dreyfus, em Seinfeld

1995: Christine Baranski, em Cybill Lisa Kudrow, em Friends Helen Hunt, em Mad About You Candice Bergen, em Murphy Brown Julia Louis-Dreyfus, em Seinfeld

1996: Julia Louis-Dreyfus, em Seinfeld Kristen Johnston, em 3rd Rock from the Sun Christine Baranski, em Cybill Ellen DeGeneres, em Ellen Helen Hunt, em Mad About You

1997: Julia Louis-Dreyfus, em Seinfeld Calista Flockhart, em Ally McBeal Ellen DeGeneres, em Ellen Helen Hunt, em Mad About You Kirstie Alley, em Veronica's Closet

1998: Tracey Ullman, em Tracey Takes On... Calista Flockhart, em Ally McBeal Amy Pietz, wm Caroline in the City Lisa Kudrow, em Friends Julia Louis-Dreyfus, em Seinfeld

1999: Lisa Kudrow, em Friends Calista Flockhart, em Ally McBeal Lucy Liu, em Ally McBeal Sarah Jessica Parker, em Sex and the City Tracey Ullman, em Tracey Takes On...

Anos 2000

2000: Sarah Jessica Parker, em Sex and the City Calista Flockhart, em Ally McBeal Jane Kaczmarek, em Malcolm in the Middle Debra Messing, em Will & Grace Megan Mullally, em Will & Grace

2001: Megan Mullally, em Will & Grace Patricia Heaton, em Everybody Loves Raymond Jennifer Aniston, em Friends Kim Cattrall, em Sex and the City Sarah Jessica Parker, em Sex and the City

2002: Megan Mullally, em Will & Grace Patricia Heaton, em Everybody Loves Raymond Jennifer Aniston, em Friends Jane Kaczmarek, em Malcolm in the Middle Kim Cattrall, em Sex and the City

2003: Megan Mullally, em Will & Grace Patricia Heaton, em Everybody Loves Raymond Doris Roberts, em Everybody Loves Raymond Lisa Kudrow, em Friends Debra Messing, em Will & Grace

2004: Teri Hatcher, em Desperate Housewives Patricia Heaton, em Everybody Loves Raymond Doris Roberts, em Everybody Loves Raymond Sarah Jessica Parker, em Sex and the City Megan Mullally, em Will & Grace

2005: Felicity Huffman, em Desperate Housewives Candice Bergen, em Boston Legal Patricia Heaton, em Everybody Loves Raymond Mary-Louise Parker, em Weeds Megan Mullally, em Will & Grace

Ano Vencedora e nomeadas/indicadas SériePapel 2006 America Ferrera Ugly Betty Betty SuarezFelicity Huffman Desperate Housewives Lynette ScavoJulia Louis-Dreyfus The New Adventures of Old Christine Christine CampbellMegan Mullally Will & Grace Karen WalkerMary-Louise Parker Weeds Nancy BotwinJaime Pressly My Name Is Earl Joy Turner 2007 Tina Fey 30 Rock Liz LemonChristina Applegate Samantha Who? Samantha NewlyAmerica Ferrera Ugly Betty Betty SuarezMary-Louise Parker Weeds Nancy BotwinVanessa L. Williams Ugly Betty Wilhelmina Slater 2008 Tina Fey 30 Rock Liz LemonChristina Applegate Samantha Who? Samantha NewlyAmerica Ferrera Ugly Betty Betty SuarezMary-Louise Parker Weeds Nancy BotwinTracey Ullman Tracey Ullman's State of the Union vários personagens 2009 Tina Fey 30 Rock Liz LemonChristina Applegate Samantha Who? Samantha NewlyToni Collette The United States of Tara Tara GregorEdie Falco Nurse Jackie Jackie PeytonJulia Louis-Dreyfus The New Adventures of Old Christine Christine Campbell

Anos 2010 AnoVencedores e nomeadosSériePapel 2010 Betty White Hot in Cleveland Elka Ostrovsky Edie Falco Nurse Jackie Jackie PeytonTina Fey 30 Rock Liz LemonJane Lynch Glee Sue SylvesterSofía Vergara Modern Family Gloria Delgado-Pritchett 2011 Betty White Hot in Cleveland Elka Ostrovsky Julie Bowen Modern Family Claire DunphySofía Vergara Gloria Delgado-PritchettEdie Falco Nurse Jackie Jackie PeytonTina Fey 30 Rock Liz Lemon 2012 Tina Fey 30 Rock Liz LemonEdie Falco Nurse Jackie Jackie PeytonAmy Poehler Parks and Recreation Leslie KnopeSofía Vergara Modern Family Gloria Delgado-PritchettBetty White Hot in Cleveland Elka Ostrovsky 2013 Julia Louis-Dreyfus Veep Selina Meyer Mayim Bialik The Big Bang Theory Amy Farrah Fowler Julie Bowen Modern Family Claire Dunphy Edie Falco Nurse Jackie Jackie Peyton Tina Fey 30 Rock Liz Lemon 2014 Uzo Aduba Orange Is the New Black Suzanne "Crazy Eyes" Warren Julie Bowen Modern Family Claire Dunphy Edie Falco Nurse Jackie Jackie Peyton Julia Louis-Dreyfus Veep Selina Meyer Amy Poehler Parks and Recreation Leslie Knope 2015 Uzo Aduba Orange Is the New Black Suzanne "Crazy Eyes" Warren Edie Falco Nurse Jackie Jackie Peyton Ellie Kemper Unbreakable Kimmy Schmidt Kimmy Schmidt Julia Louis-Dreyfus Veep Selina Meyer Amy Poehler Parks and Recreation Leslie Knope2016 Julia Louis-Dreyfus Veep Selina MeyerUzo AdubaOrange is the New BlackSuzanne "Crazy Eyes" WarrenJane FondaGrace and FrankieGrace HansonLily TomlinFrances "Frankie" BergsteinEllie KemperUnbreakable Kimmy SchmidtKimmy Schmidt 2017 Julia Louis-Dreyfus Veep Selina MeyerUzo AdubaOrange Is the New BlackSuzanne "Crazy Eyes" WarrenAlison BrieGLOWRuth WilderJane FondaGrace and FrankieGrace HansonLily TomlinFrankie Bergstein 2018 Rachel Brosnahan The Marvelous Mrs. Maisel Miriam "Midge" MaiselAlex BorsteinSusie MyersonAlison BrieGLOWRuth WilderJane FondaGrace and FrankieGrace HansonLily TomlinFrankie Bergstein 2019 Phoebe Waller-Bridge Fleabag FleabagChristina ApplegateDead to MeJen HardingAlex BorsteinThe Marvelous Mrs. MaiselSusie MyersonRachel BrosnahanMiriam "Midge" MaiselCatherine O'HaraSchitt's CreekMoira Rose

Anos 2020 AnoVencedores e nomeadosSériePapel 2020 Catherine O'Hara || rowspan="2"; style="background:#B0C4DE;" |Schitt's Creek Moira Rose |- |Annie Murphy ||Alexis Rose |- |Christina Applegate ||rowspan="2"|Dead to Me ||Jean Harding |- |Linda Cardellini ||Judy Hale |- |Kaley Cuoco ||The Flight Attendant ||Cassie Bowden |- | rowspan="5" style="text-align:center;"| 2021 || style="background:#B0C4DE;"| Jean Smart Hacks || style="background:#B0C4DE;"| Deborah Vance |- |Elle Fanning || The Great || Catarina, a Grande |- |Hannah Waddingham || rowspan="2"|Ted Lasso || Rebecca Walton |- |Juno Temple || Keeley Jones |- |Sandra Oh || The Chair || Ji-Yoon Kim |- | rowspan="5" style="text-align:center;"| 2022 || style="background:#B0C4DE;"| Jean Smart || style="background:#B0C4DE;" |Hacks Deborah Vance |- |Christina Applegate || Dead to Me || Jen Harding |- |Rachel Brosnahan || The Marvelous Mrs. Maisel || Miriam "Midge" Maisel |- |Quinta Brunson || Abbott Elementary || Janine Teagues |- |Jenna Ortega || Wednesday || Wednesday Addams |- | rowspan="5" style="text-align:center;"| 2023 || style="background:#B0C4DE;"| Ayo Edebiri The Bear || style="background:#B0C4DE;"| Sydney Adamu |- |Rachel Brosnahan || rowspan="2" | The Marvelous Mrs. Maisel || Miriam "Midge" Maisel |- |Alex Borstein || Susie Myerson |- |Quinta Brunson || Abbott Elementary || Janine Teagues |- |Hannah Waddingham || Ted Lasso || Rebecca Welton |- | rowspan="5" style="text-align:center;"| 2024 || style="background:#B0C4DE;"| Jean Smart || style="background:#B0C4DE;" |Hacks Deborah Vance |- |Kristen Bell || Nobody Wants This || Joanne |- |Ayo Edebiri || rowspan="2" | The Bear || Sydney Adamu |- |Liza Colón-Zayas || Tina |- |Quinta Brunson || Abbott Elementary || Janine Teagues |- | rowspan="5" style="text-align:center;"| 2025 || style="background:#B0C4DE;"| Catherine O'Hara The Studio || style="background:#B0C4DE;"| Patty LeighJenna Ortega Wednesday Wednesday AddamsKathryn Hahn The Studio Maya MasonJean Smart Hacks Deborah VanceKristen Wiig Palm Royale Maxine Simmons

A SAG