La temporada 2021-22 de la 2. Bundesliga correspondió a la 48.ª edición de la Segunda División de Alemania. La fase regular comenzó a disputarse el 23 de julio de 2021 y terminó el 15 de mayo de 2022.
Sistema de competición Participaron en la 2. Bundesliga 18 clubes que, siguiendo un calendario establecido por sorteo, se enfrentaron entre sí en dos partidos, uno en terreno propio y otro en campo contrario. El ganador de cada partido obtuvo tres puntos, el empate otorgó un punto y la derrota, cero puntos.
El torneo se disputó entre los meses de mayo de 2021 y mayo de 2022. Al término de la temporada, los dos primeros clasificados ascendieron a la 1. Bundesliga, y el tercer clasificado disputó su ascenso con el antepenúltimo clasificado de la 1. Bundesliga. Los dos últimos descendieron a la 3. Liga y el antepenúltimo clasificado disputó su permanencia con el tercer clasificado de la 3. Liga.
Relevo anual de clubes {| |- style="vertical-align: top;" | Pos17.°Werder Bremen18.°Schalke 04 Pos1.°Bochum 2.°Greuther Fürth Pos16.°Osnabrück17.°Eintracht Brunswick 18.°Wurzburgo Kickers Pos1.°Dinamo Dresde2.°Hansa Rostock3.°Ingolstadt 04
Clubes participantes
ClubCiudadEstadioAforo SV Darmstadt 98 Darmstadt Merck-Stadion am Böllenfalltor 16 500 Dinamo Dresde Dresde Rudolf-Harbig-Stadion 32 066 Hannover 96 Hannover HDI-Arena 49 000 FC Hansa Rostock Rostock Ostseestadion 29 000 FC Heidenheim Heidenheim an der Brenz Voith-Arena 15 000 Fortuna Düsseldorf Düsseldorf Merkur Spiel-Arena 54 600 Holstein Kiel Kiel Holstein-Stadion 11 522 Jahn Ratisbona Ratisbona Jahnstadion Regensburg 15 224 FC Núremberg Núremberg Max-Morlock-Stadion 46 780 Karlsruher SC Karlsruhe Wildparkstadion 32 306 SC Paderborn 07 Paderborn Benteler-Arena 15 000 Hamburgo SV Hamburgo Volksparkstadion 57 000 FC Ingolstadt 04 Ingolstadt Audi Sportpark 15 445 SV Sandhausen Sandhausen BWT-Stadion am Hardtwald 12 100 FC San Pauli Hamburgo Millerntor-Stadion 29 546 FC Erzgebirge Aue Aue-Bad Schlema Sparkassen-Erzgebirgsstadion 16 000 FC Schalke 04 Gelsenkirchen Veltins-Arena 69 271 Werder Bremen Bremen Wohninvest Weserstadion 42 100
Equipos por estados federados
RegiónN.ºEquipos25px|border Renania del Norte-Westfalia3Fortuna Düsseldorf, Schalke 04 y Paderborn 0725px|border Baden-Württemberg3Heidenheim, Sandhausen y Karlsruher25px|border Baviera3Ingolstadt 04, Núremberg y Jahn Ratisbona25px|border Hamburgo2San Pauli y Hamburgo SV25px|border Sajonia2Dinamo Dresde y Erzgebirge Aue25px|border Baja Sajonia1Hannover 9625px|border Bremen1Werder Bremen25px|border Hesse1Darmstadt 98 25px|border Schleswig-Holstein1Holstein Kiel25px|border Mecklemburgo-Pomerania1Hansa Rostock
Clasificación
Evolución de las posiciones Actualizado el . Jornada /Equipo12345678910111213141516171819202122232425262728293031323334 Schalke 04<small>14<small>10<small>10<small>13<small>9<small>7<small>11<small>8<small>4<small>3<small>3<small>3<small>5<small>7<small>6<small>8<small>4<small>4<small>6<small>4<small>5<small>5<small>5<small>5<small>6<small>5<small>4<small>4<small>1<small>1<small>2<small>1<small>1<small>1Werder Bremen<small>8<small>6<small>11<small>9<small>7<small>3<small>8<small>11<small>8<small>10<small>10<small>10<small>8<small>9<small>10<small>9<small>9<small>7<small>4<small>3<small>3<small>2<small>1<small>1<small>1<small>3<small>2<small>1<small>2<small>2<small>1<small>3<small>2<small>2Hamburgo<small>4<small>5<small>8<small>7<small>10<small>9<small>6<small>7<small>7<small>8<small>6<small>7<small>7<small>6<small>5<small>7<small>3<small>3<small>5<small>5<small>4<small>3<small>2<small>4<small>5<small>7<small>6<small>7<small>6<small>6<small>5<small>4<small>3<small>3Darmstadt 98<small>15<small>17<small>12<small>10<small>8<small>11<small>9<small>12<small>9<small>6<small>7<small>6<small>4<small>1<small>2<small>2<small>2<small>2<small>2<small>1<small>1<small>4<small>3<small>2<small>2<small>1<small>3<small>2<small>4<small>4<small>3<small>2<small>4<small>4San Pauli<small>2<small>4<small>4<small>5<small>4<small>5<small>3<small>2<small>1<small>1<small>1<small>1<small>1<small>2<small>1<small>1<small>1<small>1<small>1<small>2<small>2<small>1<small>4<small>3<small>3<small>2<small>1<small>3<small>3<small>3<small>4<small>5<small>5<small>5Heidenheim<small>10<small>7<small>7<small>8<small>11<small>10<small>7<small>3<small>6<small>9<small>11<small>8<small>9<small>8<small>8<small>6<small>8<small>6<small>3<small>6<small>6<small>6<small>6<small>7<small>7<small>6<small>7<small>6<small>7<small>7<small>8<small>8<small>8<small>6Paderborn 07<small>11<small>11<small>5<small>3<small>2<small>2<small>1<small>4<small>3<small>4<small>5<small>4<small>3<small>3<small>4<small>4<small>6<small>9<small>8<small>9<small>8<small>8<small>8<small>8<small>8<small>8<small>8<small>8<small>8<small>8<small>7<small>7<small>6<small>7Núremberg<small>12<small>12<small>6<small>6<small>5<small>6<small>4<small>5<small>5<small>5<small>4<small>5<small>6<small>5<small>7<small>5<small>7<small>5<small>9<small>7<small>7<small>7<small>7<small>6<small>4<small>4<small>5<small>5<small>5<small>5<small>6<small>6<small>7<small>8Holstein Kiel<small>18<small>18<small>18<small>18<small>15<small>15<small>15<small>14<small>15<small>15<small>15<small>16<small>13<small>16<small>12<small>14<small>15<small>12<small>13<small>11<small>10<small>10<small>11<small>11<small>11<small>13<small>12<small>12<small>11<small>11<small>12<small>9<small>9<small>9Düsseldorf<small>5<small>8<small>14<small>11<small>12<small>12<small>13<small>10<small>12<small>12<small>9<small>11<small>12<small>12<small>13<small>11<small>12<small>13<small>14<small>15<small>15<small>16<small>13<small>13<small>13<small>11<small>13<small>13<small>13<small>13<small>13<small>10<small>10<small>10Hannover 96<small>7<small>14<small>15<small>15<small>17<small>14<small>12<small>13<small>13<small>14<small>14<small>14<small>15<small>15<small>16<small>15<small>13<small>15<small>12<small>13<small>14<small>13<small>12<small>12<small>12<small>14<small>14<small>14<small>14<small>14<small>15<small>14<small>14<small>11Karlsruher<small>3<small>1<small>3<small>4<small>6<small>8<small>5<small>9<small>10<small>7<small>8<small>9<small>10<small>10<small>9<small>10<small>10<small>10<small>10<small>10<small>11<small>11<small>9<small>9<small>9<small>9<small>9<small>9<small>9<small>10<small>9<small>12<small>11<small>12Hansa Rostock<small>13<small>9<small>9<small>12<small>13<small>13<small>14<small>15<small>14<small>13<small>13<small>12<small>11<small>11<small>11<small>13<small>14<small>14<small>15<small>14<small>12<small>14<small>15<small>16<small>15<small>12<small>11<small>11<small>12<small>12<small>11<small>13<small>12<small>13<small>16<small>16<small>16<small>14<small>14<small>16<small>16<small>16<small>16<small>16<small>16<small>15<small>16<small>17<small>17<small>17<small>17<small>16<small>16<small>16<small>16<small>15<small>16<small>15<small>14<small>15<small>15<small>15<small>15<small>15<small>14<small>15<small>15<small>14Ratisbona<small>6<small>2<small>1<small>1<small>1<small>1<small>2<small>1<small>2<small>2<small>2<small>2<small>2<small>4<small>3<small>3<small>5<small>8<small>7<small>8<small>9<small>9<small>10<small>10<small>10<small>10<small>10<small>10<small>10<small>9<small>10<small>11<small>13<small>15Dinamo Dresde<small>1<small>3<small>2<small>2<small>3<small>4<small>10<small>6<small>11<small>11<small>12<small>13<small>14<small>13<small>14<small>12<small>11<small>11<small>11<small>12<small>13<small>12<small>14<small>14<small>16<small>16<small>16<small>16<small>16<small>16<small>16<small>16<small>16<small>16Erzgebirge Aue<small>8<small>13<small>13<small>16<small>18<small>18<small>18<small>18<small>17<small>18<small>17<small>17<small>17<small>14<small>15<small>16<small>16<small>17<small>17<small>17<small>17<small>17<small>18<small>17<small>17<small>17<small>17<small>17<small>18<small>17<small>17<small>17<small>17<small>17Ingolstadt 04<small>17<small>15<small>17<small>17<small>16<small>17<small>17<small>17<small>18<small>17<small>18<small>18<small>18<small>18<small>18<small>18<small>18<small>18<small>18<small>18<small>18<small>18<small>17<small>18<small>18<small>18<small>18<small>18<small>17<small>18<small>18<small>18<small>18<small>18
Resultados Los horarios corresponden al huso horario de Alemania (Hora central europea): UTC+1 en horario estándar y UTC+2 en horario de verano.
Primera vuelta Jornada 1LocalResultadoVisitanteEstadioFechaHoraSchalke 041 - 3HamburgoVeltins-Arena23 de julio20:30Darmstadt 980 - 2Jahn RatisbonaMerck-Stadion am Böllenfalltor24 de julio13:30Heidenheim0 - 0Paderborn 07Voith-ArenaDinamo Dresde3 - 0Ingolstadt 04Rudolf-Harbig-StadionHansa Rostock1 - 3KarlsruherOstseestadionWerder Bremen1 - 1Hannover 96Wohninvest Weserstadion20:30San Pauli3 - 0Holstein KielMillerntor-Stadion25 de julio13:30Núremberg0 - 0Erzgebirge AueMax-Morlock-StadionSandhausen0 - 2Fortuna DüsseldorfBWT-Stadion am Hardtwald Jornada 2LocalResultadoVisitanteEstadioFechaHoraKarlsruher3 - 0Darmstadt 98Wildparkstadion30 de julio18:30Paderborn 072 - 2NúrembergBenteler-ArenaHannover 960 - 3Hansa RostockHDI-Arena31 de julio13:30Jahn Ratisbona3 - 0SandhausenJahnstadion RegensburgIngolstadt 041 - 2HeidenheimAudi SportparkFortuna Düsseldorf2 - 3Werder BremenMerkur Spiel-Arena20:30Holstein Kiel0 - 3Schalke 04Holstein-Stadion1 de agosto13:30Hamburgo1 - 1Dinamo DresdeVolksparkstadionErzgebirge Aue0 - 0San PauliSparkassen-Erzgebirgsstadion Jornada 3LocalResultadoVisitanteEstadioFechaHoraSchalke 041 - 1Erzgebirge AueVeltins-Arena13 de agosto18:30San Pauli3 - 2HamburgoMillerntor-StadionHolstein Kiel0 - 3Jahn RatisbonaHolstein-Kiel14 de agosto13:30Núremberg2 - 0Fortuna DüsseldorfMax-Morlock-StadionSandhausen0 - 0KarlsruherBWT-Stadion am HardtwaldDinamo Dresde2 - 0Hannover 96Rudolf-Harbig-Stadion20:30Werder Bremen1 - 4Paderborn 07Wohninvest Weserstadion15 de agosto13:30Darmstadt 986 - 1Ingolstadt 04Merck-Stadion am BöllenfalltorHeidenheim1 - 1Hansa RostockVoith-Arena Jornada 4LocalResultadoVisitanteEstadioFechaHoraFortuna Düsseldorf2 - 2Holstein KielMerkur Spiel-Arena20 de agosto18:30Hannover 961 - 0HeidenheimHDI-ArenaKarlsruher0 - 0Werder BremenWildparkstadion21 de agosto13:30Paderborn 073 - 1San PauliBenteler-ArenaJahn Ratisbona4 - 1Schalke 04Jahnstadion RegensburgHansa Rostock1 - 3Dinamo DresdeOstseestadion20:30Hamburgo2 - 2Darmstadt 98Volksparkstadion22 de agosto13:30Erzgebirge Aue1 - 3SandhausenSparkassen-ErzgebirgsstadionIngolstadt 040 - 0NúrembergAudi Sportpark Jornada 5LocalResultadoVisitanteEstadioFechaHoraNúremberg2 - 1KarlsruherMax-Morlock-Stadion27 de agosto18:30Sandhausen0 - 2Ingolstadt 04BWT-Stadion am HardtwaldHolstein Kiel3 - 0Erzgebirge AueHolstein-Stadion28 de agosto13:30Darmstadt 984 - 0Hannover 96Merck-Stadion am BöllenfalltorHeidenheim0 - 0HamburgoVoith-ArenaSchalke 043 - 1Fortuna DüsseldorfVeltins-Arena20:30Werder Bremen3 - 0Hansa RostockWohninvest Weserstadion29 de agosto13:30San Pauli2 - 0Jahn RatisbonaMillerntor-StadionDinamo Dresde0 - 3Paderborn 07Rudolf-Harbig-Stadion Jornada 6LocalResultadoVisitanteEstadioFechaHoraKarlsruher2 - 2Holstein KielWildparkstadion11 de septiembre13:30Hannover 961 - 0San PauliHDI-ArenaIngolstadt 040 - 3Werder BremenAudi SportparkHamburgo2 - 1SandhausenVolksparkstadion20:30Heidenheim2 - 1Dinamo DresdeVoith-Arena12 de septiembre13:30Paderborn 070 - 1Schalke 04Benteler-ArenaErzgebirge Aue0 - 1Fortuna DüsseldorfSparkassen-ErzgebirgsstadionJahn Ratisbona2 - 2NúrembergJahnstadion RegensburgHansa Rostock2 - 1Darmstadt 98Ostseestadion