Carol Remmer Angle es una pediatra, nefróloga, y toxicóloga estadounidense, es reconocida como una de las principales investigadoras en saturnismo.
Biografía Es profesora emérita del Centro Médico de la Universidad de Nebraska (UNMC) en Omaha, Nebraska. Desarrolla actividades científicas y académicas en la UNMC desde 1971 y fue una de las primeras mujeres en ser presidente de un departamento médico académico (pediatría). Ha sido también Jefa de nefrología pediátrica, directora de la unidad de Cuidados intensivos pediátricos, y director de toxicología médica. En 1957, la Dra. Angle along with Dr. Matilda McIntire, founded one of the country’s first poison control centers. La Dra. Angle es miembro fundadora y presidenta de la American Association of Poison Control Centers. Por cuarenta años, sirvió como experta del NIEHS, National Institutes of Health y de la Agencia de Protección Ambiental de Estados Unidos donde se investiga la toxicidad de metales pesados. Sigue como consultora de toxicología, revisora y editora.
Formación Wellesley College; Cornell Medical College School; New York Hospital Pediatric, Internado y Residencia; University of Nebraska Hospital, Residency
Reconocimiento Directora, Educación Médica, Childrens Memorial Hospital, Omaha, Nebraska, 1954-1967 Directora, Centro de Control de Tóxicos Nebraska Master, 1957-1966 Coordinadora Estadual, Nebraska Master Poison Control Center, 1957-1966 Directora, Clínica Pediátrica Renal, Univ. de Nebraska Hospital & Clínicas, 1966-1984 Directora, Unidad Pediátrica de Cuidados Intensivos, Univ. de Nebraska Hospital, 1968-1974 Presidenta del Programa, Asociación Americana de Centros de Control Toxicológico, 1977-1979 Profesora, Dto de Pediatría, Univ. de Nebraska Fac. de Medicina, 1971-1998 Directora, Fundación Nacional del Centro de Tratamiento de Defectos Congénitos, Children's Memorial Hospital, 1974-1981 Miembro, Toxicology Advisory Board, U.S. Consumer Product Safety Commission, 1978-1982 Chairman, Department of Pediatrics, University of Nebraska College of Medicine, 1981-1985 Miembro, National Advisory Environmental Health Sciences Council, NIH, 1984-1987 Directora, Clinical Toxicology, University of Nebraska Medical Center, 1985-1998 Editora jefa, Journal of Toxicology - Clinical Toxicology, 1989-2002 Profesora emérita, Dto. de Pediatría, University of Nebraska College of Medicine, 1999–present Honor Award, Matthew J. Ellenhorn Award, 2003 Galardón de Honor, University of Nebraska Medical Center Legends Award, 2008
Publicaciones Angle CR: Congenital bowing and angulation of long bones. Pediatrics 13:257-267, 1954
Angle CR: Poison control outlines: toxicity of insecticides and herbicides. Nebr Med J 48:644-646, 1963
Angle CR and McIntire MS: Lead poisoning during pregnancy: fetal tolerance of calcium disodium edentate. Am J Dis Child 108:436-439, 1964
Angle CR: Acute renal failure. J Lancet 86:355-362, 1966
Angle CR and McIntire MS: Evaluation of a poison information center. J Lancet 86:363-365, 1966
Angle CR, McIntire MS and Moore, RC: Cloverleaf skull: Kleeblattschadel-deformity syndrome. Am J Dis Child 114:098-202, 1967
Angle CR, McIntire MS and Zetterman RA: CNS symptoms in childhood poisoning. Clin Toxicol 1:19-29, 1968 Angle CR, McIntire MS and Meile R: Neurologic sequelae of poisoning in children. J Pediat 73:531-539, 1968 Angle CR and McIntire MS: Persistent dystonia in a brain damaged child after ingestion of phenothiazine. J Pediat 73:124-126, 1968
Angle CR and Glyn M: The value of a pediatric high intensity care unit. Nebr Med J 54:737-740, 1969
Angle CR: Symposium on iron poisoning. Clin Tox 4:525-527, 1971
Angle CR and McIntire MS: Red cell lead, whole blood lead and red cell enzymes. Environ Health Perspect 7:133-137, 1974
Angle CR and Wermers J: Human poisoning with flea-dip concentrate. J Am Vet Med Assc 165:174-175, 1974
Angle CR, McIntire MS and Vest BS: Blood lead of Omaha school children topographic correlation with industry, traffic and housing. Nebr Med J 60:97-102, 1975
Angle CR: Locomotor skills and school accidents. Pediatrics 56:819-822, 1975
Angle CR, McIntire MS and Brunk G: Effect of anemia on blood and tissue lead in rats. J Toxicol Environ Health 3:557-563, 1977
Angle CR, Trembath EJ and Strond W: The myelodysplasia and hydrocephalus program in Nebraska: A 15 year review of cost and benefits, Park I. Nebr Med J 62:359-361 (Oct), 1977; Part II. Nebr Med J 63:391-939 (nov) 1977
Angle CR and McIntire MS: Lead, mercury and cadmium: toxicity in children. Paediatrician 6:204-225, 1977
Angle CR and McIntire MS: Low level lead and inhibition of erythrocyte pyrimidine nucleotidase. Environ Res 17:296-302, 1978
Angle CR and McIntire MS: Environmental lead and children – the Omaha Study. J Toxicol Environ Health 5:855-870, 1979
Angle CR, Stohs SJ, McIntire MS, Swanson MS and Rovang K: Lead induced accumulation of erythrocyte pyrimidine nucleotides in the rabbit. Toxicol Appl Pharmacol 54:161-167, 1980
Angle CR: The Department of Pediatrics, UNMC. Neb Med J 53-54, 1981
Angle CR, McIntire MS, Swanson MS and Stohs SJ: Erythrocyte nucleotides in children – increased blood lead and cytidine triphosphate. Pediatr Res 16:331-334, 1982
Angle CR, O’Brien TP and McIntire MS: Adolescent self-poisoning – a 9 year follow-up. JDBP 4:83-87, 1983
Angle CR, Marcus A, Cheng I and McIntire MS: Omaha childhood blood lead and environmental lead: A linear exposure model. Environ Res 35:160-170, 1984
Angle CR, Swanson MS, Stohs SJ and Markin RS: Abnormal erythrocyte pyrimidine nucleotides in uremic subjects. Nephron 39:169-174, 1985
Angle CR and Kuntzelman DR: Increased erythrocyte protoporphyrins and blood lead – A pilot study of childhood growth patterns. J Toxicol Environ Health 26:149-156, 1989
Angle CR, Thomas DJ and Swanson SA: Toxicity of cadmium to rat osteosarcoma cells (ROS 17/2.8): Protective effect of 1,25 dihydroxy vitamin D3. Toxicol Appl Pharmacol 103:113-120, 1990
Angle CR, Thomas DJ and Swanson SA: Lead inhibits the basal and stimulated responses of a rat osteoblast-like cell line ROS 17/2.8 to 1,25 dihydroxyvitamine D3 and IGF-I. Toxicol Appl Pharmacol 103:281-287, 1990
Angle CR, Thomas DJ, Swanson SA: Osteotoxicity of cadmium and lead in HOS TE 85 and ROS 17/2.8 cells: Relation to metallothionein induction and mitochondrial binding. BioMetals 5:179-184, 1993
Angle CR, Manton WI, Stanek KL. Stable isotope Identification of Lead Sources in Preschool Children-the Omaha Study. J Toxicol Clin Toxicol 33:657-62, 1995
Angle CR, Swanson SA: Arsenite enhances homocysteine-induced proliferation of fibroblasts in human aortic smooth muscle cells in B12 (Cobalamin) deficient media. Submitted to Environmental Health Perspectives, julio de 1997
Angle CR. Pitfalls of correlation of childhood blood lead and cognitive development. J Toxicol Clin Toxicol 40(4):521-2, 2002
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Categoría:Científicas de Estados Unidos Categoría:Pediatras de Estados Unidos Categoría:Toxicólogos Categoría:Alumnado del Wellesley College Categoría:Profesores de la Universidad de Nebraska-Lincoln Categoría:Escritores en inglés del siglo XX Categoría:Mujeres del siglo XX